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J Dent Educ. 65(10): 1054-1062 2001
© 2001 American Dental Education Association
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Journal of Dental Education, Vol 65, Issue 10, 1054-1062
Copyright © 2001 by American Dental Education Association

Articles

Physical and chemical aspects of saliva as indicators of risk for dental caries in humans

CW Leone and FG Oppenheim

The etiology and pathogenesis of dental caries are known to be multifactorial, but the interplay between intrinsic and extrinsic factors is still not fully understood. As in other host/parasite interactions, there appear to be marked variations in individual susceptibility to the disease. It therefore is likely that intrinsic host factors play a key role in modulating the initiation and progression of caries. The objective of this systematic review was to evaluate critically the evidence supporting the role and effects of saliva in caries pathogenesis. The full-length evidence report, including evidence tables, and the structured abstract presented at the NIH/NIDCR Consensus Development Conference on the Diagnosis and Management of Dental Caries Throughout Life, March 26-28. 2001, can be accessed at the web site http://www.nidcr.nih.gov. The present abridged report is a summary of the main findings from our evidence-based review.


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